Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease
Identifieur interne : 000460 ( France/Analysis ); précédent : 000459; suivant : 000461Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease
Auteurs : Aurélie Funkiewiez [France] ; Claire Ardouin [France] ; Paul Krack [France] ; Valérie Fraix [France] ; Nadège Van Blercom [France] ; Jing Xie [France] ; Elena Moro [France] ; Alim-Louis Benabid [France] ; Pierre Pollak [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-05.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Activities of Daily Living, Aged, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (therapeutic use), Antiparkinson agent, Bilateral, Chemotherapy, Cognition Disorders (diagnosis), Cognition Disorders (physiopathology), Depressive Disorder, Major (diagnosis), Electric Stimulation Therapy (instrumentation), Female, Frontal Lobe (physiopathology), Functional Laterality, Human, Humans, Instrumental stimulation, Levodopa, Levodopa (administration & dosage), Levodopa (therapeutic use), Male, Middle Aged, Mood, Neuropsychological Tests, Parkinson Disease (drug therapy), Parkinson Disease (psychology), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Psychological Tests, Psychomotor Disorders (diagnosis), Psychotropic, Questionnaires, Severity of Illness Index, Subthalamic Nucleus (physiology), Subthalamic nucleus, Time, Treatment, deep brain stimulation, euphoria, levodopa, mood, subthalamic nucleus.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- diagnosis : Cognition Disorders, Depressive Disorder, Major, Psychomotor Disorders.
- drug therapy : Parkinson Disease.
- instrumentation : Electric Stimulation Therapy.
- physiology : Subthalamic Nucleus.
- physiopathology : Cognition Disorders, Frontal Lobe.
- psychology : Parkinson Disease.
- therapy : Parkinson Disease.
- Activities of Daily Living, Aged, Female, Functional Laterality, Humans, Male, Middle Aged, Neuropsychological Tests, Psychological Tests, Questionnaires, Severity of Illness Index, Time.
Abstract
High‐frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves the motor symptoms of Parkinson's disease (PD). Opposite changes in mood, such as mania or depression, have been reported after surgery, but it is not known whether these side effects are specifically related to STN DBS. To learn whether STN DBS also influences the limbic loop, we investigated acute subjective psychotropic effects related to levodopa or bilateral STN DBS. After a median postoperative follow‐up of 12 months, 50 PD patients completed the Addiction Research Center Inventory (ARCI), assessing subjective psychotropic effects in four conditions: off‐drug/on‐stimulation; off‐drug/off‐stimulation; on‐drug/off‐stimulation; and on‐drug/on‐stimulation. Both levodopa and STN DBS improved all the ARCI subscales, indicating subjective feelings of well being, euphoria, increase in motivation, and decrease in fatigue, anxiety, and tension. A suprathreshold dose of levodopa was significantly more effective than STN DBS, using the same electrical parameters as for chronic stimulation, on four of the five ARCI subscales. We concluded that 1) both STN DBS and levodopa have synergistic acute beneficial psychotropic effects in PD, 2) the psychotropic effects of both treatments need to be considered in the long‐term management of chronic STN DBS, and 3) the results indicate an involvement of the limbic STN in mood disorders of PD. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10441
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000725
- to stream Istex, to step Curation: 000725
- to stream Istex, to step Checkpoint: 002B16
- to stream PubMed, to step Corpus: 003794
- to stream PubMed, to step Curation: 003794
- to stream PubMed, to step Checkpoint: 003872
- to stream Ncbi, to step Merge: 000A57
- to stream Ncbi, to step Curation: 000A57
- to stream Ncbi, to step Checkpoint: 000A57
- to stream Main, to step Merge: 005E09
- to stream PascalFrancis, to step Corpus: 002451
- to stream PascalFrancis, to step Curation: 000870
- to stream PascalFrancis, to step Checkpoint: 002545
- to stream Main, to step Merge: 006091
- to stream Main, to step Curation: 004186
- to stream Main, to step Exploration: 004186
- to stream France, to step Extraction: 000460
Links to Exploration step
ISTEX:A300B348DE718838110366E71FB11E28194C2609Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease</title><author><name sortKey="Funkiewiez, Aurelie" sort="Funkiewiez, Aurelie" uniqKey="Funkiewiez A" first="Aurélie" last="Funkiewiez">Aurélie Funkiewiez</name></author><author><name sortKey="Ardouin, Claire" sort="Ardouin, Claire" uniqKey="Ardouin C" first="Claire" last="Ardouin">Claire Ardouin</name></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadège" last="Van Blercom">Nadège Van Blercom</name></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author><author><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A300B348DE718838110366E71FB11E28194C2609</idno><date when="2003" year="2003">2003</date><idno type="doi">10.1002/mds.10441</idno><idno type="url">https://api.istex.fr/document/A300B348DE718838110366E71FB11E28194C2609/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000725</idno><idno type="wicri:Area/Istex/Curation">000725</idno><idno type="wicri:Area/Istex/Checkpoint">002B16</idno><idno type="wicri:doubleKey">0885-3185:2003:Funkiewiez A:acute:psychotropic:effects</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:12722166</idno><idno type="wicri:Area/PubMed/Corpus">003794</idno><idno type="wicri:Area/PubMed/Curation">003794</idno><idno type="wicri:Area/PubMed/Checkpoint">003872</idno><idno type="wicri:Area/Ncbi/Merge">000A57</idno><idno type="wicri:Area/Ncbi/Curation">000A57</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A57</idno><idno type="wicri:doubleKey">0885-3185:2003:Funkiewiez A:acute:psychotropic:effects</idno><idno type="wicri:Area/Main/Merge">005E09</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:03-0381006</idno><idno type="wicri:Area/PascalFrancis/Corpus">002451</idno><idno type="wicri:Area/PascalFrancis/Curation">000870</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002545</idno><idno type="wicri:doubleKey">0885-3185:2003:Funkiewiez A:acute:psychotropic:effects</idno><idno type="wicri:Area/Main/Merge">006091</idno><idno type="wicri:Area/Main/Curation">004186</idno><idno type="wicri:Area/Main/Exploration">004186</idno><idno type="wicri:Area/France/Extraction">000460</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease</title><author><name sortKey="Funkiewiez, Aurelie" sort="Funkiewiez, Aurelie" uniqKey="Funkiewiez A" first="Aurélie" last="Funkiewiez">Aurélie Funkiewiez</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Ardouin, Claire" sort="Ardouin, Claire" uniqKey="Ardouin C" first="Claire" last="Ardouin">Claire Ardouin</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadège" last="Van Blercom">Nadège Van Blercom</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2003-05">2003-05</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="524">524</biblScope><biblScope unit="page" to="530">530</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A300B348DE718838110366E71FB11E28194C2609</idno><idno type="DOI">10.1002/mds.10441</idno><idno type="ArticleID">MDS10441</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term><term>Aged</term><term>Antiparkinson Agents (administration & dosage)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Antiparkinson agent</term><term>Bilateral</term><term>Chemotherapy</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (physiopathology)</term><term>Depressive Disorder, Major (diagnosis)</term><term>Electric Stimulation Therapy (instrumentation)</term><term>Female</term><term>Frontal Lobe (physiopathology)</term><term>Functional Laterality</term><term>Human</term><term>Humans</term><term>Instrumental stimulation</term><term>Levodopa</term><term>Levodopa (administration & dosage)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Mood</term><term>Neuropsychological Tests</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (therapy)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Psychological Tests</term><term>Psychomotor Disorders (diagnosis)</term><term>Psychotropic</term><term>Questionnaires</term><term>Severity of Illness Index</term><term>Subthalamic Nucleus (physiology)</term><term>Subthalamic nucleus</term><term>Time</term><term>Treatment</term><term>deep brain stimulation</term><term>euphoria</term><term>levodopa</term><term>mood</term><term>subthalamic nucleus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term><term>Depressive Disorder, Major</term><term>Psychomotor Disorders</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electric Stimulation Therapy</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cognition Disorders</term><term>Frontal Lobe</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Aged</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Psychological Tests</term><term>Questionnaires</term><term>Severity of Illness Index</term><term>Time</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Antiparkinsonien</term><term>Bilatéral</term><term>Chimiothérapie</term><term>Homme</term><term>Humeur</term><term>Lévodopa</term><term>Noyau sousthalamique</term><term>Parkinson maladie</term><term>Psychotrope</term><term>Stimulation instrumentale</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High‐frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves the motor symptoms of Parkinson's disease (PD). Opposite changes in mood, such as mania or depression, have been reported after surgery, but it is not known whether these side effects are specifically related to STN DBS. To learn whether STN DBS also influences the limbic loop, we investigated acute subjective psychotropic effects related to levodopa or bilateral STN DBS. After a median postoperative follow‐up of 12 months, 50 PD patients completed the Addiction Research Center Inventory (ARCI), assessing subjective psychotropic effects in four conditions: off‐drug/on‐stimulation; off‐drug/off‐stimulation; on‐drug/off‐stimulation; and on‐drug/on‐stimulation. Both levodopa and STN DBS improved all the ARCI subscales, indicating subjective feelings of well being, euphoria, increase in motivation, and decrease in fatigue, anxiety, and tension. A suprathreshold dose of levodopa was significantly more effective than STN DBS, using the same electrical parameters as for chronic stimulation, on four of the five ARCI subscales. We concluded that 1) both STN DBS and levodopa have synergistic acute beneficial psychotropic effects in PD, 2) the psychotropic effects of both treatments need to be considered in the long‐term management of chronic STN DBS, and 3) the results indicate an involvement of the limbic STN in mood disorders of PD. © 2003 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li></settlement><orgName><li>Centre hospitalier universitaire Grenoble Alpes</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Funkiewiez, Aurelie" sort="Funkiewiez, Aurelie" uniqKey="Funkiewiez A" first="Aurélie" last="Funkiewiez">Aurélie Funkiewiez</name></noRegion><name sortKey="Ardouin, Claire" sort="Ardouin, Claire" uniqKey="Ardouin C" first="Claire" last="Ardouin">Claire Ardouin</name><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadège" last="Van Blercom">Nadège Van Blercom</name><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000460 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000460 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:A300B348DE718838110366E71FB11E28194C2609
|texte= Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |